Table 5 Top 15 hub nodes identified in PPI network for DEGs from ALS fibroblast samples and control fibroblast samples
Gene | Gene Name | Degree | GO Term |
|---|---|---|---|
TNF | Tumor necrosis factor | 47 | Celladhesion/Cell-cell adhesion/ECM |
EDN1 | Endothelin 1 | 42 | Cell-cell signaling/ECM |
AGT | Angiotensin | 37 | Celladhesion/Cell-cell signaling/ECM |
WNT5A | Wingless-Type MMTV Integration site family, member 5A | 31 | Cell-cell signaling/ECM |
APOE | Apolipoprotein E | 29 | Cell-cell signaling |
VWF | Von Willebrand factor | 28 | Cell adhesion/ECM |
ACAN | Aggrecan | 24 | Celladhesion/Cell-cell adhesion/ECM |
CD36 | Thrombospondin receptor | 24 | Cell adhesion |
VTN | Vitronectin | 23 | Cell adhesion/ECM |
CD40 | TNF receptor super family member 5 | 25 | Cell adhesion molecules/Extracellular region |
NTRK2 | Neurotrophic tyrosine kinase, receptor, type 2 | 23 | Cell-cell signaling |
ITGA3 | Integrin, alpha 3 | 21 | Cell adhesion/focal adhesion |
ITGA7 | Integrin, alpha 7 | 21 | Cell adhesion/focal adhesion |
GLI1 | Zinc finger protein GLI1 | 19 | Cell-cell signaling |
TGFB2 | Transforming growth factor beta 2 | 19 | Cell-cell signaling |