Fig. 4
Changes in bone marrow fat fraction during 2.5 years of eliglustat treatment. Depicted are patient no. 3 and 4 who had the most severe decrease of fat fraction before initiation of therapy and showed most prominent increases of fat fraction upon eliglustat treatment. Fat fraction values of patient 4 before initiation of therapy ranged between 7–20 %, probably related to hormonal variation [53]. Fat fraction scores of L3, L4, and L5 are averaged. Patients with a fat fraction <0.23 have an increased risk of developing bone complications [36]