Fig. 6

Results of AGREE II appraisal for domains 1–6. The identified GLs and RCs were scored on a 7-point scale for the 23 items belonging to domain 1 (a), domain 2 (b), domain 3 (c), domain 4 (d), domain 5 (e) and domain 6 (f). Data are presented as mean ± SD of values obtained by each group of disorders in each domain. A: amino acid and organic acid metabolism (n = 8); C: carbohydrate metabolism (n = 9); E: vitamin and non protein cofactor metabolism and transport (n = 2); G: mineral absorption and transport (n = 5); H: energy metabolism (n = 3); I: lysosomal and lysosomal-related organelles (n = 27)