Fig. 4

Propranolol affects viability and caspase activation in hemangioblastoma cells. Different lines of hemangioblastoma cells were cultured in the absence or presence of propranolol (50 μM or 100 μM) to measure viability and apoptosis. The histograms show a decrease in viability (a), with a parallel increase in the activation of caspase 3/7 (b). Finally, in relation to the decreased cell viability, the ratio of apoptosis vs. viability is shown (c). Propranolol promoted a decrease in viability by increasing apoptosis in these tumor cells