Table 3 Summary of possible susceptibility genes for sIBM based on current research and discussed in this review
From: Sporadic inclusion body myositis: the genetic contributions to the pathogenesis
Classification | Regions/Genes |
|---|---|
Immune-associated genes | |
Degenerative-associated genes | APP gene[45]; PSEN gene[46]; DYSF gene[47]; APOE gene[48]; MAPT gene[49]; PRNP gene[50]; SERPINA3 gene[51]; TARDBP gene[52]; hnRNPA1 and hnRNPA2B1 genes[53]; C9orf72[54]. |
mtDNA-associated sequences/genes | mtDNA deletions[55]; Nuclear coding mitochondrial genes: TYMP, SLC25A4, C10orf2, POLG1, and TOMM40 gene[16, 56]. |