Table 2 Clinical complications in 51 symptomatic PA patients based on medical records
From: Propionic acidemia: clinical course and outcome in 55 pediatric and adolescent patients
Affected organ/organ system | Frequency in the study cohort of 55 PA patients |
|---|---|
Bone marrow | |
Pancytopenia | 11% |
Neutropenia | 29% |
Thrombocytopenia | 35% |
Anemia | 82% |
Central and peripheral nervous system | |
Psychomotor retardation | 55% |
Delayed development of the speech | 55% |
Muscular hypotonia | 51% |
Metabolic stroke | 9% |
Ataxia | 9% |
Impaired hearing ability | 13% |
Visual impairment | 7% |
Heart | |
Long-QT syndrome | 22% |
Cardiomyopathy | 9% |
Pancreas | |
Pancreatitis | 4% |
Skeletal system | |
Osteoporosis | 2% |