Table 2 Treatment for clinical symptoms of transthyretin familial polyneuropathy (TTR-FAP)
From: Guideline of transthyretin-related hereditary amyloidosis for clinicians
Symptom | Treatment |
|---|---|
Arrhythmias | Pacemaker implantation, pharmacotherapy |
Cardiac failure | Diuretics, angiotensin converting enzyme inhibitors |
Orthostatic hypotension | Droxidopa, midodrine, amezinium metisulfate, fludrocortisone, plastic stocking, abdominal belt, elevating head |
Gastrointestinal disorders (not severe) | Polycarbophil calcium, metoclopramide |
Severe diarrhea | Loperamide |
Neuropathic pain | Pregabalin, gabapentin, amitriptyline, duloxetine |
Carpal tunnel syndrome | Surgery |
Dry mouth | Potassium dihydrogen phosphate, cevimeline |
Hypoglycemia | Glucose loading |
Renal failure | Hemodialysis |
Urinary incontinence | Distigmine |
Anemia | Erythropoietin, iron |
Hypothyroidism | Levothyroxine |
Ocular amyloidosis | Vitrectomy, trabeculectomy |