Brain involvement in Alström syndrome

Table 2 Differences in regional gray and white matter volumes between AS patients and controls

Brodmann		Anatomical labels^a	No. of voxels	p-Value (FWE corrected)^b	MNI coordinates (mm)c
Grey Matter
BA22	LH	Sup Temporal	35728	0,0001	−46 0 -4
	LH	Cerebellum	793	0,0001	−16 -40 -56
BA39	RH	Middle temp gyrus	1187	0,0001	46 -74 22
BA10	RH	Sup front Gyrus	1089	0,0001	32 58 22
BA39	LH	Angular gyrus	860	0,0001	−46 -72 32
White Matter
BA17	RH	Middle Occipital	6181	0,0001	−26 -98 6
BA19	LH	Middle Occipital			−24 -74 2
BA4	RH	Precentral	3200	0,0001	42 -22 62
BA4	LH	Middle cingulum			−8 -32 46
	RH	Cerebellum	900	0,0001	24 -40 -48

^aAnatomical labels were obtained using AAL Toolbox; sup = superior; temp = temporal; front = frontal.
^b Statistical significance after correction for multiple comparisons (Family Wise Error voxel-level).
^c Montreal Neurological Institute coordinates of the voxel of maximal statistical significance within each region.
LH = left hemisphere; RH = right hemispher.

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