Figure 1

Human interactome network analysis of CHI-associated genes. (A) Genes with a known association with CHI in red were used to infer a network from the BioGRID model of the human interactome (http://thebiogrid.org/). (B) Biological pathway ontology associated with each network module has been colour coded for clarity and listed separately in Table 1; hypergeometric test false discovery rate (FDR) ≤ 0.001. The inferred network was generated using the BioGRID plugin (version 3.1.94) for Cytoscape (version 2.8.3) to identify the primary interactors of CHI genes from all known physical and genetic evidence. The CHI gene associated network inferred from the BioGRID interactome model was then imported into the Reactome Plugin for Cytoscape and modularity was analysed using spectral partition clustering [11].