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Table 2 Kinetic parameters for tyrosylation of tRNA Tyr by wild-type and p.Gly191Asp YARS2 recombinant proteins

From: Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia

YARS2 Variant

K m (Ī¼M)

kcat(min-1)

kcat/K m (Efficiency)

Loss of Efficiencya(Fold change)

WT

1

34

34

1

p.Gly191Asp

1

0.9

0.9

38

  1. aLoss of efficiency is calculated relative to the wild-type YARS2.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172