Volume 7 Supplement 1
Pathophysiology and medical treatment of pain in fibrous dysplasia of bone
© Chapurlat et al; licensee BioMed Central Ltd. 2012
Published: 24 May 2012
One of the most common complications of fibrous dysplasia of bone (FD) is bone pain. Usual pain killers are often of inadequate efficacy to control this bone pain. The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors one may consider that ectopic sprouting and formation of neuroma-like structures by sensory and sympathetic nerve fibers also occur in the dysplastic skeleton. Bone pain has been reported in up to 81% of adults and 49% of children. It affects predominantly the lower limbs and the spine. The degree of pain is highly variable and adults reports more pain than children. Bisphosphonates have been shown to reduce bone pain in uncontrolled studies. Their influence on bone strength remains unknown. In a randomized trial testing alendronate, bone pain was not significantly improved. Another trial assessing the effect of risedronate is ongoing. Possible future therapies include tocilizumab, denosumab and drugs targeting nerve growth factor and its receptor TrkA.
Fibrous dysplasia of bone (FD) is a rare disease responsible for bone deformities, fractures, nerve compression and bone pain. There are specificities in the pathophysiology of bone pain compared to other tissues, including the role of increased bone resorption. The treatment of bone pain can involve non specific drugs and bone-specific drugs, such as bisphosphonates.
We will review the pathophysiology of bone pain, the current therapeutic possibilities and the treatment perspectives.
Pathophysiology of bone pain
Pain is a common occurrence in FD and is often the presenting symptom of the disease [1–3]. When the health-related quality of life was assessed in FD subjects, both adults and children had significantly more skeletal pain than the U. S. population . A common misconception is that FD pain dissipates with age; however, recent population studies suggest that FD pain actually increases with age . The analgesics that are most commonly used to control FD pain are non-steroidal anti-inflammatory drugs (NSAIDS), bisphosphonates and opiates [2, 3]. However, lack of recognition by the medical community that FD pain can be both severe and increase in adulthood has led many FD patients to be labeled as “drug seeking” and inadequately treated . Adequate pain management of FD pain, like nearly all other types of pain, is clearly required for FD patients to maintain their functional status and quality of life.
Currently, our understanding of the factors that drive FD pain and how to best treat FD pain comes mainly from empirical studies concerning the ability of available therapies to relieve FD pain. Two seminal clinical studies included one where it was demonstrated that FD pain was attenuated following infusion of the bisphosphonate pamidronate . The second showed that there was not a clear correlation between FD pain and disease burden, and that in terms of frequency and severity FD pain increases with age . This later finding may in part be explained by the fact that whereas bone mass, density, and strength all decline with age, sensory nerve fibers that innervate bone and which sense noxious stimuli and transmit this information to the spinal cord and brain, do not appear to decline with age .
While there are currently no direct studies examining what mechanisms drive FD pain, in the last decade significant strides have begun to be made in understanding the specific populations of sensory nerve fibers that innervate the skeleton [7, 8], what mechanisms drive malignant and non-malignant skeletal pain , what molecules preferentially excite nerve fibers that innervate the bone , and what analgesic therapies may be particularly efficacious in alleviating skeletal pain .
A select population of sensory nerve fibers innervates the skeleton and drives skeletal pain
Sensory nerve fibers that innervate the skeleton can undergo a remarkable sprouting and pathological reorganization which may drive FD pain
While it is not known whether sprouting of sensory nerve fibers occurs in FD, this phenomenon has been observed in non-malignant skeletal pain states in human and animals. Previous studies have reported that human chronic discogenic pain may in part be due to a growth of TrkA+ nerve fibers into normally aneural and avascular areas of the human intervertebral disc . Other studies have demonstrated significant sprouting of CGRP+ nerve fibers following bone fracture in rat and in the arthritic joints of humans and animals [17–19]. These reports suggest that following injury or disease of the skeleton, significant sprouting of TrkA+ nerve fibers can occur, and it appears that endogenous stromal cells as well as inflammatory and immune cells are the source of NGF [14, 15].
The burden of bone pain in fibrous dysplasia
Methods and patients (adapted from Ref. 4)
We have studied a relatively large population of patients with FD in an effort to understand their experience with pain . All subjects enrolled in a National Institutes of Health (NIH) Institutional Review Board approved study of FD and MAS were invited to complete the self report Brief Pain Inventory (BPI) and a demographic data questionnaire during their initial evaluation at NIH between July 2000 and July 2005. Ninety-one subjects were enrolled during that period, and 78 (86%) completed the pain form and had a 99Tc-MDP bone scan, including 56 subjects 14 or older (72%) and 22 under the age of 14 (28%). The diagnosis of FD was established in all patients based on clinical history, histopathological findings, radiographic findings, and when necessary, an analysis of the GNAS gene for R201 mutations. Bone scans were assessed for sites of FD involvement, which were identified as areas of non-physiologic tracer uptake, and disease severity was determined using a validated scoring tool . The fact that tracer uptake sites represented FD was confirmed by radiograph and/or CT. Pain was assessed using a human figure drawing and the numeric rating scale (NRS) of the Brief Pain Inventory (BPI). The BPI is a short, self-administered questionnaire developed to assess the severity and impact of pain primarily in cancer patients . It has been shown to be valid and reliable in adults when used to assess cancer pain , chronic and acute nonmalignant pain and pain in osteoarthritis patients. The goal was to assess pain “intrinsic” to the FD and not pain that occurred in relation to a fracture. Therefore, acute or healing fractures were excluded from the analysis (i.e., > 6 months since radiographic evidence of complete healing at a site at which there had been a recent fracture). Analgesic use and perceived relief information was obtained as part of the questionnaire, and confirmed during patient interviews.
The study population was made up of a group of subjects with a broad spectrum of disease, from isolated monostotic FD, to total skeletal involvement. The lower extremities were the sites most likely to be affected by FD (86% of adults, 97% of children, p=NS for differences between adults and children). The head was also commonly affected (86% of adults, 94% of children, p=NS). FD lesions were found less frequently in the upper extremities (72% of adults, 89% of children, p=NS), the ribs (72% of adults, 57% of children, p=NS) and the spine (72% of adults, 46% of children, p<0.05). The spine was the only site at which there was a significant increase in FD involvement over time.
Prevalence of pain by age groups
Age group (years)
% of subjects with pain
There was no correlation between pain prevalence and gender, phosphate wasting, vitamin D status (serum vitamin D level < 32 ng/ml was used as a cutoff for the diagnosis of vitamin D deficiency), or any endocrinopathy in children. Growth hormone excess correlated with pain prevalence at FD sites in adults (p=0.031).
Pain severity, treatment and response to treatment1
% with releif
% with releif
Treatment of fibrous dysplasia bone pain with bisphosphonates
The use of an antiresorptive agent in the treatment of an osteoblastic lineage disease, such as FD, is counterintuitive. The rationale for doing so is based on the presence of abundant osteoclastic bone resorption within and around the fibrous tissue. Therefore, in an early study that took as an example the treatment of Paget’s disease, 9 patients were treated with intravenous pamidronate (180 mg every 6 months), with striking radiographic improvements and decreases in bone pain and biochemical markers of bone remodeling . Patients were also receiving calcium (500-1500 mg/day) and vitamin D (800-1200 IU/day) supplements.
Long-term effects of this regimen have been assessed with additional patients and longer follow-up, still in an open design, with similar results [2, 22]. A dose of 3 mg/kg/treatment cycle was used in children and adolescents, who represented 30% of this cohort. Fifty-eight patients have been treated with intravenous pamidronate and followed-up for an average 50 months (ranging from 1 to 11 years). Pain intensity was reduced after the first course of treatment, with an additive effect observed after several treatment cycles. Bone pain disappeared in 60% of these patients, diminished in 24% and did not improve in 16% of them. In parallel, biochemical markers of bone turnover – such as total alkaline phosphatase, serum osteocalcin, and urinary CTX – were also significantly reduced compared to baseline. Half of those treated patients had discernable radiological improvement, characterized by filling of osteolytic lesions and/or cortical thickening. In addition, total hip bone mineral density (BMD) measured in patients who had hip involvement was substantially increased . Results were similar in adults and children or adolescents. These biochemical and radiological changes, however, were not associated with bone pain reduction.
Favorable outcomes have also been observed in other open studies using intravenous pamidronate, administered at 6-month intervals. Thus, bone pain was significantly relieved in a study involving 7 patients with various forms of FD treated with intravenous pamidronate . A greater increase in BMD was also observed in affected areas than in unaffected areas, using whole body DXA to compare the affected to the unaffected side, after 1 year of treatment. Simultaneously, the level of bone turnover as assessed by biochemical markers was reduced but most patients still had increased bone turnover.
A few patients have also been treated successfully with alendronate. For example, an increase of 158% in total hip BMD over 2 years has been observed in a 22-year old woman who had received four 90 mg infusions of pamidronate every 4 weeks, followed by oral alendronate 10 mg/day , with a parallel relief in bone pain and decrease in urinary NTX. In another case report , a 45-year old woman who received alendronate 5 mg/day was relieved of her bone pain after several months of treatment. Bone turnover was diminished and the radiological appearance improved slightly. In a series of 6 adult patients who had been treated with pamidronate followed by alendronate or who had used alendronate alone, bone pain decreased substantially in response to therapy, bone resorption was reduced with intravenous pamidronate but not with oral alendronate, and four out of six patients exhibited radiological improvement .
Although most patients respond favorably to pamidronate therapy, a subset (15% in our group's experience, RDC) did not exhibit any improvement in bone pain. Other patients, with an initial positive response to treatment with pamidronate, have suffered from a relapse of bone pain or failed to maintain reduced levels of biochemical markers of bone turnover. When those patients who relapsed or failed treatment with pamidronate were switched to zoledronic acid, we were not able to obtain significant reductions in bone pain or improvement in the radiographic appearance . Zoledronic acid was well-tolerated, with only two patients with an acute phase reaction associated with the first infusion. Those patients switched to zoledronic acid tended to have more serious disease than the other patients on pamidronate only.
In another study , however, no convincing evidence of radiographic benefit could be observed in 18 children and adolescents with polyostotic FD, despite significant reduction in levels of bone turnover markers. The explanation for the discrepancy between this study conducted in young patients and those in adults or other pediatric series [30–32] remains unclear, but some of the difference might relate to the absence of use of phosphate supplements in those patients with renal phosphate wasting. The difference may also stem from the difficulty in defining appropriate radiographic outcomes in studies of FD, as lesions are heterogeneous and radiographs are not always reproducible over time.
All these results were obtained in uncontrolled open studies. The role of the placebo effect and regression to the mean is likely to explain some of the effect on bone pain. The radiologic effect might be confounded by the age-related sclerosis of lesions , but this phenomenon arises over long periods of time, whereas the improvement associated with bisphosphonate use could be observed over shorter periods of time, e.g., 2-3 years. These shortcomings led to the design of two randomized placebo-controlled clinical trials, one conducted in the USA to test alendronate , and the other in Europe, the PROFIDYS trial, testing risedronate . The results of the first trial are not yet published, and the latter is still recruiting patients.
Some patients fail to respond to bisphosphonates or relapse after an initial improvement in bone pain. These individuals do not seem to respond better to more potent bisphosphonates, such as zoledronic acid . Those patients often have severe polyostotic disease, with a history of several fractures, substantial bone pain, and sometimes optic nerve compression. There is no current satisfactory therapeutic option in these severely disabled patients whose disease is resistant to bisphosphonates.
We know that GNAS mutations result in abnormal proliferation and differentiation of bone marrow stromal cells. In those osteoblastic cells, IL-6 secretion is increased as a result of Gs activation, with consequent activation of surrounding osteoclasts, allowing the FD lesion to expand and create osteolytic lesions . A direct link has been established between the GNAS mutation in stromal cells and IL-6 production, so that FD, which is an osteoblastic lineage disorder, is also often associated with a hyperosteoclastic component .
This is the rationale to selectively inhibit the IL-6 driven increased bone resorption that is observed in FD by targeting the IL-6 receptor with tocilizumab, in those patients who fail to respond to bisphosphonates primarily or secondarily. Tocilizumab - a human monoclonal antibody to IL-6 receptor - is a drug currently used in rheumatoid arthritis (RA) treatment. It can reduce symptoms, and block localized periarticular bone loss induced by the disease. A recent study has also shown that the level of systemic bone resorption, as assessed by markers such as serum ICTP and CTX could be significantly decreased in RA in response to tocilizumab .
Therefore, a randomized placebo-controlled cross-over trial testing the value of tocilizumab to decrease bone resorption among patients with FD who do not respond to bisphosphonate therapy will be launched in Europe in 2011. A total of 12 patients will receive either tocilizumab during 6 months followed by 6 months of placebo (6 patients), or 6 months of placebo followed by 6 months of tocilizumab (6 patients). The study is powered to show a 30% difference in bone resorption between the two treatments. Decrease in bone resorption (primary endpoint) will be assessed with serum CTX. Secondary endpoints will be: decrease in bone pain, assessed by visual analogic scale in the most painful skeletal site, decrease in other markers of bone remodeling (serum osteocalcin, bone alkaline phosphatase, P1NP), and improvement in the short-form 36 (SF-36) quality of life scale.
Therapies that may be useful in treating FD pain
CURRENT AND POTENTIAL THERAPIES FOR TREATMENT OF FIBROUS DYSPLASIA PAIN
Inhibition of bone remodeling/
Osteoclast activity suppression
Stimulates opioid receptors
Blockade of peripheral and central sensitization
Recently approved therapies/ ongoing clinical trials for treating other skeletal pain states
Blocks osteoclast activation
Inhibition of bone remodeling/
Blockade of peripheral sensitization
Blockade of nerve sprouting
Developing sensory and sympathetic nerve fibers
NGF/TrkA inhibitors (Array, JNJ, Abbott)
Blockade of peripheral sensitization
Blockade of pH sensitive neurons
Developing sensory and sympathetic nerve fibers
TRPV1 antagonists (Pfizer, JNJ, Abbott, Merck, GSK, etc.)
Blockade of pH sensitive neurons
CSFR1 inhibitors response (Plexxikon, Roche, JNJ)
Inhibition of CSFR1
Reduction in osteoclasts, macrophages, etc.
Decreased immune response to infection
Calcium channel, α2, δ1 subunit
Aberrant neuronal discharge
Denosumab is currently approved to treat osteoporosis as it targets RANKL and is remarkably effective at reducing osteoclast-induced bone remodeling. As such it may represent a potential treatment for FD bone pain. Pregabalin has been shown to attenuate a wide variety of neuropathic pain (i.e. pain originating from damaged or ectopic reorganization of nerve fibers) and as ectopic reorganization of nerve fibers may play an important role in driving FD induced skeletal pain, pregabalin might be useful in reducing FD pain, however no clinical study data currently exists that specifically investigates the efficacy of pregabalin in FD.
Bone pain is commonly observed in FD. Bisphosphonates can provide some relief of bone pain, but the development of mechanism-based therapies to treat neuropathic bone pain or the bone disease itself is needed to improve the management of FD patients.
This article has been published as part of Orphanet Journal of Rare Diseases Volume 7 Supplement 1, 2012: International Meeting on Fibrous Dysplasia/McCune-Albright Syndrome and Cherubism. The full contents of the supplement are available online at http://www.ojrd.com/supplements/7/S1. Publication of the proceedings was funded by the Fibrous Dysplasia Foundation and an unrestricted grant from Zimmer.
- Firat D, Stutzman L: Fibrous dysplasia of the bone. Review of twenty-four cases. Am J Med. 1968, 44: 421-429. 10.1016/0002-9343(68)90112-5.View ArticlePubMedGoogle Scholar
- Chapurlat RD, Delmas PD, Liens D, Meunier PJ: Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. J Bone Miner Res. 1997, 12 (10): 1746-52. 10.1359/jbmr.1918.104.22.1686.View ArticlePubMedGoogle Scholar
- Kelly MH, Brillante B, Collins MT: Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions. Osteoporos Int. 2008, 19: 57-63. 10.1007/s00198-007-0425-x.View ArticlePubMedGoogle Scholar
- Kelly MH, Brillante B, Kushner H, Gehron Robey P, Collins MT: Physical function is impaired but quality of life preserved in patients with fibrous dysplasia of bone. Bone. 2005, 37: 388-394. 10.1016/j.bone.2005.04.026.View ArticlePubMedGoogle Scholar
- Liens D, Delmas PD, Meunier PJ: Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. Lancet. 1994, 343 (8903): 953-4. 10.1016/S0140-6736(94)90069-8.View ArticlePubMedGoogle Scholar
- Jimenez-Andrade JM, Mantyh WG, Bloom AP, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW: The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain. Neurobiol Aging. 2010, 33: 921-932.PubMed CentralView ArticlePubMedGoogle Scholar
- Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW: A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain. Bone. 2011, 46: 523-529. 10.1016/j.bone.2009.09.013.Google Scholar
- Zylka MJ, Rice FL, Anderson DJ: Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005, 45: 17-25. 10.1016/j.neuron.2004.12.015.View ArticlePubMedGoogle Scholar
- Mantyh PW: Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci. 2006, 7: 797-809.View ArticlePubMedGoogle Scholar
- Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, Smith MD, Brown MT: Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med. 2010, 363: 1521-1531. 10.1056/NEJMoa0901510.View ArticlePubMedGoogle Scholar
- Mantyh WG, Jimenez-Andrade JM, Stake JI, Bloom AP, Kaczmarska MJ, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW: Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience. 2010, 171: 588-598. 10.1016/j.neuroscience.2010.08.056.PubMed CentralView ArticlePubMedGoogle Scholar
- Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE, Ghilardi JR, Rosol TJ, Boustany L, Shelton DL, Mantyh PW: A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Res. 2005, 65: 9426-9435. 10.1158/0008-5472.CAN-05-0826.View ArticlePubMedGoogle Scholar
- Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA, Mantyh PW: Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci. 2010, 30: 14649-14656. 10.1523/JNEUROSCI.3300-10.2010.PubMed CentralView ArticlePubMedGoogle Scholar
- Skaper SD, Pollock M, Facci L: Mast cells differentially express and release active high molecular weight neurotrophins. Brain Res Mol Brain Res. 2001, 97: 177-185.View ArticlePubMedGoogle Scholar
- Ehrhard PB, Erb P, Graumann U, Otten U: Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc Natl Acad Sci USA. 1993, 90: 10984-10988. 10.1073/pnas.90.23.10984.PubMed CentralView ArticlePubMedGoogle Scholar
- Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, Ross ER, O'Brien JP, Hoyland JA: Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol. 2002, 197: 286-292. 10.1002/path.1108.View ArticlePubMedGoogle Scholar
- Ashraf S, Wibberley H, Mapp PI, Hill R, Wilson D, Walsh DA: Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis. Ann Rheum Dis. 2011, 70: 523-529. 10.1136/ard.2010.137844.View ArticlePubMedGoogle Scholar
- Suri S, Gill SE, Massena de Camin S, Wilson D, McWilliams DF, Walsh DA: Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheum Dis. 2007, 66: 1423-1428. 10.1136/ard.2006.063354.PubMed CentralView ArticlePubMedGoogle Scholar
- Wu Z, Nagata K, Iijima T: Involvement of sensory nerves and immune cells in osteophyte formation in the ankle joint of adjuvant arthritic rats. Histochem Cell Biol. 2002, 118: 213-220.PubMedGoogle Scholar
- Collins MT, Kushner H, Reynolds JC, Chebli C, Kelly MH, Gupta A, et al: An instrument to measure skeletal burden and predict functional outcome in fibrous dysplasia of bone. J Bone Miner Res. 2005, 20 (2): 219-226.View ArticlePubMedGoogle Scholar
- Daut RL, Cleeland CS, Flanery RC: Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain. 1983, 17 (2): 197-210. 10.1016/0304-3959(83)90143-4.View ArticlePubMedGoogle Scholar
- Chapurlat RD, Hugueny P, Delmas PD, Meunier PJ: Treatment of fibrous dysplasia of bone with intravenous pamidronate: long-term effectiveness and evaluation of predictors of response to treatment. Bone. 2004, 35 (1): 235-42. 10.1016/j.bone.2004.03.004.View ArticlePubMedGoogle Scholar
- Chapurlat R, Meunier PJ: The nonsurgical treatment of fibrous dysplasia. Rev Rhum Engl Ed. 1999, 66 (1): 1-3.PubMedGoogle Scholar
- Parisi MS, Oliveri B, Mautalen CA: Effect of intravenous pamidronate on bone markers and local bone mineral density in fibrous dysplasia. Bone. 2003, 33 (4): 582-8. 10.1016/S8756-3282(03)00221-7.View ArticlePubMedGoogle Scholar
- Weinstein RS: Long-term aminobisphosphonate treatment of fibrous dysplasia: spectacular increase in bone density. J Bone Miner Res. 1997, 12 (8): 1314-5. 10.1359/jbmr.1922.214.171.1244.View ArticlePubMedGoogle Scholar
- Kitagawa Y, Tamai K, Ito H: Oral alendronate treatment for polyostotic fibrous dysplasia: a case report. J Orthop Sci. 2004, 9 (5): 521-5.View ArticlePubMedGoogle Scholar
- Lane JM, Khan SN, O'Connor WJ, Nydick M, Hommen JP, Schneider R, Tomin E, Brand J, Curtin J: Bisphosphonate therapy in fibrous dysplasia. Clin Orthop Relat Res. 2001, 382: 6-12.View ArticlePubMedGoogle Scholar
- Chapurlat RD: Medical therapy in adults with fibrous dysplasia of bone. J Bone Miner Res. 2006, 21 (Suppl 2): P114-9.View ArticlePubMedGoogle Scholar
- Plotkin H, Rauch F, Zeitlin L, Munns C, Travers R, Glorieux FH: Effect of pamidronate treatment in children with polyostotic fibrous dysplasia of bone. J Clin Endocrinol Metab. 2003, 88 (10): 4569-75. 10.1210/jc.2003-030050.View ArticlePubMedGoogle Scholar
- Lala R, Matarazzo P, Bertelloni S, Buzi F, Rigon F, de Sanctis C: Pamidronate treatment of bone fibrous dysplasia in nine children with McCune-Albright syndrome. Acta Paediatr. 2000, 89 (2): 188-93. 10.1111/j.1651-2227.2000.tb01214.x.View ArticlePubMedGoogle Scholar
- Isaia GC, Lala R, Defilippi C, Matarazzo P, Andreo M, Roggia C, Priolo G, de Sanctis C: Bone turnover in children and adolescents with McCune-Albright syndrome treated with pamidronate for bone fibrous dysplasia. Calcif Tissue Int. 2002, 71 (2): 121-8. 10.1007/s00223-001-1098-7.View ArticlePubMedGoogle Scholar
- Zacharin M, O’Sullivan M: Intravenous pamidronate treatment of polyostotic fibrous dysplasia associated with the McCune-Albright syndrome. J Pediatr. 2000, 137 (3): 403-9. 10.1067/mpd.2000.107836.View ArticlePubMedGoogle Scholar
- Kuznetsov SA, Cherman N, Riminucci M, Collins MT, Gehron Robey P, Bianco P: Age-dependent demise of GNAS-mutated skeletal stem cells and “normalization” of fibrous dysplasia of bone. J Bone Miner Res. 2008, 23 (11): 1741-40. 10.1359/jbmr.080704.View ArticleGoogle Scholar
- Yamamoto T, Ozono K, Kasayama S, Yoh K, Hiroshima K, Takagi M, Matsumoto S, Michigami T, Yamaoka K, Kishimoto T, Okada S: Increased IL-6 production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome. J Clin Invest. 1996, 98: 30-5. 10.1172/JCI118773.PubMed CentralView ArticlePubMedGoogle Scholar
- Riminucci M, Kuznetsov SA, Cherman N, Corsi A, Bianco P, Gehron Robey P: Osteoclastogenesis in fibrous dysplasia of bone : in situ and in vitro analysis of IL-6 expression. Bone. 2003, 33: 434-42. 10.1016/S8756-3282(03)00064-4.View ArticlePubMedGoogle Scholar
- Garnero P, Mareau E, Thompson E, Woodworth T, Smolen J: Rapid and sustained improvement in bone and cartilage markers with the interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate. Arthritis Rheum. 2010, 62: 33-43. 10.1002/art.25053.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.