Lysosomal storage disorder in non-immunological hydrops fetalis (NIHF) - more common than assumed? Report of four cases with transient NIHF and a review of the literature
© Whybra et al.; licensee BioMed Central Ltd. 2012
Received: 12 April 2012
Accepted: 7 October 2012
Published: 8 November 2012
Lysosomal storage disorders (LSD) are a rare cause of non immunological hydrops fetalis (NIHF) and congenital ascites. The reported incidence is about 1%. The incidence of idiopathic NIHF is estimated to be about 18%.
Patients and methods
We report four cases with transient hydrops fetalis resulting from LSD and performed a literature review on LSD with NIHF and congenital ascites in combination.
At present, 12 different LSDs are described to be associated with NIHF or congenital ascites. Most patients had a family history of NIHF, where the preceding sibling had not been examined. A diagnostic approach to the fetus with NIHF due to suspected LSD either in utero or postnatal is suggested. Transient forms of NIHF and/or ascites in association with MPS IVA, MPS VII and NPC are described for the first time in this publication.
LSD should be considered in transient hydrops. Enzymatic studies in chorionic villous sample or amniotic cultured cells, once the most common conditions associated with fetal ascites or hydrops have been ruled out, are important. This paper emphasizes the fact that LSD is significantly higher than the estimated 1% in previous studies, which is important for genetic counseling as there is a high risk of recurrence and the availability of enzyme replacement therapy for an increasing number of LSD.
KeywordsNon-immunological hydrops fetalis Lysosomal storage disease Transient hydrops Congenital ascites Clinical approach
Hydrops fetalis is a serious fetal condition defined as an abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural and/or pericardial effusion, and skin edema. In some patients, it may also be associated with polyhydramnion and placental edema. Isolated congenital ascites is usually considered as part of the clinical picture of hydrops fetalis, in which the severity of peripheral edema is of a mild degree and ascites is the dominant clinical sign[1, 2]. Hydrops fetalis has been a well-recognized fetal and neonatal condition throughout history. Before routine immunization of Rh-negative mothers in the 1970s, most cases of immunological hydrops were due to erythroblastosis from Rh alloimmunization. More recent recognition of factors other than isoimmune hemolytic disease that can cause or be associated with hydrops fetalis led to the use of the term non-immunological hydrops fetalis (NIHF). Currently, NIHF (reported incidence of 1 in 2000–3000 pregnancies) is more common, comprising 85-90% of all described cases[4, 5]. The precise incidence of hydrops fetalis is difficult to elucidate, because many cases are not detected prior to intrauterine fetal death and some cases may resolve spontaneously in utero. Although the incidence is very low, NIHF accounts for a disproportionate share (3%) of overall mortality in the perinatal period[6–8].
Inborn errors of metabolism (IEM) may cause hydrops fetalis. Most of these are lysosomal storage diseases. Today, around 14 different lysosomal storage diseases (LSD) have been reported as being associated with NIHF and congenital ascites[9–11]. The cause of the accumulation of excessive fluid within the peritoneal cavity in infants with LSD is a source of considerable controversy in the literature. The mechanism contributing to the development of hydrops fetalis in storage diseases may involve the obstruction of venous blood return resulting from visceromegaly secondary to accumulation of storage material. Anemia may be a trigger, being caused by either hypersplenism or the reduction of erythropoietic stem cells caused by infiltrating storage cells. Other conditions that may trigger ascites in LSD are congestive heart failure, hypoproteinaemia and liver dysfunction.
In this paper we present four cases with transient NIHF and a literature review on the incidence of LSD in NIHF. A diagnostic approach to the patient with NIHF or ascites due to suspected LSD either in utero or postnatally is established.
The purpose of this work is to report four cases, which have in common a transient hydrops fetalis, normal appearance in the postnatal period and progressive deterioration with time. All of them were diagnosised as LSD. Until now transient hydrops fetalis in association with LSD has been barely reported[14, 15]. A mortality rate of 100% of IEM in association with a NIHF is assumed, however, transient NIHF with a good perinatal outcome has hardly been described.
In a term male neonate of non-consanguineous parents with two healthy siblings (birth weight 3250 g, length 48 cm, head circumference 36 cm, Apgar Score 9/9/10, umbilical artery pH 7,24), prenatal ultrasound revealed hydrops fetalis with ascites at as early as 24 weeks of gestation. Prenatal infection was ruled out in fetal blood and any immunological causes were excluded. Amniocentesis showed a normal male karyotype. After birth he was breathing spontaneously. He had a normal phenotypic appearance, bilateral inguinal hernia and a mild hepatosplenomegaly, but no detectable ascites or pleural effusion. Echocardiography and ophthalmological examination were normal. Neonatal cholestasis and icterus praecox with elevated direct bilirubin was assessed. Hepato-IDA-scintigraphy showed patent extrahepatic biliary duct. Liver biopsy revealed foamy cells typically seen in Niemann Pick disease. Enzymatic measurements showed normal values for sphingomyelinase, ß-glucosidase, sialidase and acid lipase, excluding Niemann Pick A disease (NPA), Gaucher disease and Wolman disease. Variant Filipin staining led to the misdiagnosis of NPC. Neonatal cholestasis was treated with ursodeoxycholic acid, and then resolved spontaneously. Although the patient showed nearly normal neurological development (slight language development retardation), mild joint contractures and bilateral avascular necrosis of the femoral head, NPC as the slowly progressive form was suspected. Eight years later, the patient was presented in our clinic for a trial of substrate reduction therapy of NPC. The patient had no elevation of chitotriosidase and no horizontal saccades typical for NPC. In contrast, eye examination revealed corneal clouding. In addition, hip dysplasia was seen. Detection of the deficiency of ß-glucuronidase (0,0069 mU/ml) finally yielded the diagnosis of MPS VII.
In this case, the parents were consanguineous. The mother had had two previous pregnancies with spontaneous abortion. In the third pregnancy the fetus presented with intrauterine hydrops fetalis. The male preterm was born at 29 weeks of gestation by Caesarian sectio because of premature labour (birth weight 1550 g, length 41 cm, head circumference 27,5 cm, umbilical artery pH 7, 12). His neonatal period was uncomplicated. He could walk at age 20 months and showed minor mental retardation. At age one and a half years he developed a kyphoscoliosis. The diagnosis of MPS IVA by detection of N-acetyl-glucosamin-6-sulfat sulfatase deficiency with a residual activity of 0.234 nmol/mg/17 h ( normal 12–26 nmol/mg/17 h) was only made four years later due to continuing disproportionate growth retardation (length far below 3rd percentile) and skeletal abnormalities (thoracolumbar gibbus, ulnar deviation).
The male fetus presented with intrauterine ascites at 30 weeks of gestation. Prenatal infection was ruled out in fetal blood and any immunological causes were excluded. Amniocentesis showed a normal male karyotyp. The male neonate, born at 36 weeks of gestation presented with slight ascites, which resolved during the first weeks. Neonatal jaundice was prolonged for eight weeks and was accompanied by mild cholestatic liver enzyme elevation. He had a normal phenotypic appearance. After one year, hepatosplenomegaly was found in the routine examination of the child. The chitotriosidase was elevated (2504 nmol/ml/h, normal range 20–100 nmol/ml/h). Sphingomyelinase, ß-Glucosidase and ß-Glucuronidase were normal. Subsequently, NPC was suspected. Bone marrow punction revealed storage cells typical for NPC. Positive Filipin staining ensured the diagnosis. RFLP (restriction fragment length polymorphism) showed mutations in the NPC1 Gene.
Review of the literature
A systematic review in PubMed of the pertinent literature, especially including those reported cases or case series with LSD associated with NIHF and congenital ascites, was carried out. Studies on prenatal ultrasonography, extensive pre- and postnatal investigations and postmortem pathological examination were taken into consideration. No date limit was set.
Results and discussion
Causes of non-immunological hydrops fetalis and their relative frequency 
urinary tract malformation
inborn errors of metabolism
According to that study, no definite cause can be found in about 18% of cases of non-immunological hydrops. Chromosomal abnormalities constituted the chromosomal group, whereas syndromes, defined as clusters of structural malformations, constituted the syndromic group. Inborn errors of metabolism were excluded and constituted a separate group including LSD. The authors distinguished between a proven or very likely etiology and a suspected etiology. Regarding the high number (18%) of idiopathic NIHF, cases of suspected etiology were included in the idiopathic group.
Reported incidence of lysosomal storage disorder and inborn errors of metabolism, respectively in 13 different studies on NIHF or congenital ascites
Total number of patients
10-yr review of coded diagnosis of neonatal ascites
NIHF patients (28 pregnancies between 16 and 32 weeks, 5 newborns)
Literature review of HF case series (1980-1989)
Literature review of NIHF with focus on genetic disorders (1982-1990)
NIHF detected by fetal ultrasound
AF due to abnormal ultrasound findings (54 cases NIHF)
14.3% - 18%
Pregnancies 14-36 weeks of gestation, AF or cultured amniocytes
5.3% - 8%
Fetal ascites of NIHF detected by routine ultrasound during the second or third trimester
Sonographic evaluation 13-34 weeks of gestation with NIHF
Literature review of NIHF
NIHF, retrospective review of a large national data set (1996-2005)
Review all autopsy cases with HF over an 11- yr period
NIHF fetuses and newborns with focus on fetal cerebral ultrasounds
Most of the LSDs with hydrops fetalis are autosomal, recessively-inherited disorders with a recurrence risk of 25%. Thus, correct diagnosis is essential for genetic counseling and family planning. There is still some uncertainty about the relative frequency of LSD in NIHF, which may be underestimated. An underlying metabolic disease may be the etiology of a substantial number of these unexplained cases. In recent years it has been recognised that hydrops fetalis may be an extreme presentation of many of the lysosomal storage disorders. It can be hypothesized that lysosomal enzymes and their pathways are bi-functional and hereby different in utero. This may lead to an NIHF which requires further investigation. Usually hydrops fetalis is the most severe phenotype of some LSDs, caused by two deleterious mutations with a complete deficiency of the enzyme or transport protein. In the most severe form of LSD we usually have a good phenotype-genotype correlation, for example, the deletion 84GG always manifests as a collodian-baby in Gaucher disease. On the other hand, Niemann-Pick A does not manifest as an HF even with two knock- out mutations. The two cases reported with NPA and NIHF are an exception and may be due to secondary epigenetic factors.
Lysosomal storage diseases and non- lysosomal inborn errors of metabolism associated with NIHF
Lysosomal storage diseases
Non-lysosomal inborn errors of metabolism
NIHF with prominent ascites
NIHF (pericardial and/or pleural effusion, ascites, skin edema)
MPS IVA (this publication)
Congenital disorder of glycosylation:
MPS VII (this publication)
Fatty acid oxidation defects:
Long-chain-hydroxyacyl CoA dehydrogenase deficiency (LCHAD)
Primary carnitine deficiency
Gaucher Type II
Cholesterol biosynthesis defects:
Greenberg syndrome: Hydrops-ectopic calcification moth-eaten skeletal dysplasia
Conradi Huenermann: Chondrodysplasia punctata (X linked disorder: male fetus)
Lysosomal transport defect:
Infantile sialic acid storage disease
Infantile sialic acid storage disease
Mucolipidosis Type II (I-cell disease)
S-adenosylhomocysteine hydrolase deficiency
Congenital erythropoietic porphyria
LSD in association with hydrops fetalis
There are a variety of descriptions of Type 2 Gaucher disease presenting with hydrops fetalis. In the majority of cases with this severe phenotype including a collodian membrane, glucocerebrosidase activity is absent or severely deficient[23, 24, 29, 55, 58, 71–74]. Type 2 Gaucher disease is the rarest and most severe type, and untreated patients uniformly die before one year of age.
Cases of neonatal Sialidosis presenting as hydrops fetalis or with neonatal ascites have been reported[11, 24, 29, 45, 47–49, 74–76]. NIHF has been reported in galactosialidosis[48, 49, 75]. Claeys et al. described a patient who presented prenatally with massive ascites and was diagnosed only after birth as having galactosialidosis. Burin et al. reported hydrops with I-cell disease and NPA.
MPS IVA (Morquio disease) is a rare disease, prenatal manifestations of the disease include hydrops fetalis[33, 34]. MPS VII has also been recognized as a cause of NIHF, which is actually the most common presentation of the disease[35, 73]. However, there is great variability in the associated clinical and biochemical manifestations. The reported case I of this publication seems to emphasize this variability. A preterm infant of 29 weeks of gestation with Farber disease and severe hydrops fetalis is reported[9, 60].
Congenital ascites in association with LSD
There have been at least five descriptions of cases with NIHF or congenital ascites, either transient or persistent, as the presenting symptom of GM1 gangliosidosis[15, 51, 74]. As in case IV of this publication, Maconochie et al. described a patient with severe congenital ascites who had been diagnosed with NPC, and Meizner et al. reported a case of NIHF in which NPC was diagnosed by electron microscopy. Although Wolman disease is usually accompanied by mild ascites, Uno et al. and Ben-Haroush et al. each described a case with isolated massive milky ascetic fluid. ISSD have been described in patients with massive fetal ascites. Daneman et al. looked at four newborns with LSD, in whom the dominant presenting clinical feature was ascites. The diseases included Gaucher disease, GM I gangliosidosis, Sialidosis, and ISSD. Abdominal distention due to ascites and hepatosplenomegaly and hypoplastic lungs were seen in all patients.
Transient NIHF in association with LSD
In the literature two cases of transient NIHF in association with LSD are described. The first case occurred as early as 28 weeks of gestation and otherwise uneventful pregnancy of a non-consanguineous couple. At birth he had mild dysmorphic features and mild hepatosplenomegaly. After three days, neurological deterioration was observed and successively the diagnosis of GM1 gangliosidosis was made. The second case of transient hydrops reported (week 28 of gestation) was also a GM1 gangliosidosis and diagnosed on the basis of pathological placental findings after birth. The patients reported in this publication with transient hydrops in association with MPS IVA, MPS VII and NPC are the first described cases in the literature.
Suggested diagnostic approach
Staretz-Chacham and colleagues proposed an algorithm for the clinical evaluation of a fetus or newborn with NIHF. Where there is facial dysmorphism, irregularity of the epiphyses, and coarse trabeculations of the long bones in the presence of congenital ascites, the index of suspected storage disease is even greater.
Diagnostic approach for NIHF and suspected lysosomal storage disease
Examination of the fetus with NIHF/ascites in utero
Examination of the dead fetus with NIHF
Examination of the live neonate with NIHF
1. Amniotic fluid GAG-electrophoresis*, lysosomal enzymes elevated in ML II
1.Postnatal autopsy should be discussed in every individual fetus
1. Placental tissue for histological analysis. Culture of this tissue is also possible (cell lines often show early senescence)
If possible elctronmicroscopy for abnormal lysosomal shingolipid storage- NPC)
2. Amnion cells/Chorionic villi: enzyme measurements of ß-Glucocerebrosidase (Gaucher disease), N-Acetyl-Glukosamin-6-Sulfatsulfatase (MPS IVA), ß-Glucoronidase (MPS VII), Neuraminidase and ß-Galactosidase (Galactosialidosis, GM1 Gangliosidosis and Sialidosis). Ceramidase (Farber disease), Acid lipase (Wolman disease), Sphingomyelinase (NPA)
2. Urine for oligosaccharides and GAG-electrophoresis
2. Skin biopsy: DNA isolation for genetics and cultivated cells for biochemical tests (enzyme analysis)
3. Screening test in Plasma/Serum: I-cell screen**, chitotriosidase
4. Blood smear: vacuolated granulocytes and Adler granulation (GM1-gangliosidosis, Galactosialidosis, Sialidosis, ISSD, MPS VII)
If possible electronmicroscopy
3. Tissue sample (unfixed) e.g. liver, spleen, heart, and muscle for histopathological and histochemical examinations.
5: Considering bone marrow aspiration to look for foam cells, Gaucher cells and other storage histiocytes)
4. Placental tissue for histological analysis. Culture of this tissue is also possible (cell lines often show early senescence)
6. Skeletal-radiography: dysostosis multiplex, pathological fractures (ML II)
If possible elctronmicroscopy for abnormal lysosomal shingolipid storage- NPC)
5. Fetal urine (if available) for Glycosaminoglycans or Oligosaccharides
3. Genetic analysis: amnion cells or chorion villi cells
7. Skin biopsy: (best with eccrine glands) DNA isolation for genetics and cultivated cells for biochemical tests (enzyme analysis), Filipin test*** for NPC, abnormal lysosomal free sialic acid storage (ISSD)
If possible electronmicroscopy
8. Leucocytes and plasma (also possible in fibroblasts): measuring lysosomal enzymes of ß-Glucocerebrosidase (Gaucher), N-Acetyl-Glukosamin-6-Sulfatsulfatase (MPS IVA), ß-Glucoronidase (MPS VII), Neuraminidase and ß-Galactosidase (Galactosialidosis, GM1 Gangliosidosis and Sialidosis) Ceramidase (Farber disease). Acid lipase (Wolman disease), Sphingomyelinase (NPA).
9. EDTA-blood for DNA isolation
It is very important to examine the placenta carefully in cases where hydrops or ascites are present at birth or detected by ultrasound, especially in the transient form. Placental histology can serve as an early diagnostic clue for a number of storage diseases, including GM1 gangliosidosis, MPS VII, ISSD, Gaucher disease, galactosialidosis and Fabry disease. The presence of highly vacuolated cells or cells demonstrating storage should be followed up with enzymatic testing in patients. Even if a family does not agree to autopsy, placental examination may be done. In some instances, examination of the placenta of a grossly macerated fetus may be more informative than that of the fetus. Unfortunately this was not done in the patients reported in this publication.
Because most LSDs are inherited in an autosomal recessive manner we have to consider the importance of possible consanguinity. Often, reported patients had an antecedent sibling who was also affected but not diagnosed. This was true in the family history of case III of this publication. For this reason, in cases of familial NIHF, one should consider the LSDs or other IEM.
Nelson et al. described a case of MPS VII in consanguineous parents who had three previous unsuccessful pregnancies because of recurrent stillbirths. Landau et al. described a family in which fetal hydrops occurred in four pregnancies, and the diagnosis of galactosialidosis was only made after the birth of the fourth affected child. Gillan reported eight cases of neonatal ascites associated with different types of LSD: sialidosis, ISSD, GM1 gangliosidosis, and Gaucher disease. In each case there was a history of sibling perinatal death resulting from the disease. Manning et al. described the case of a twelfth pregnancy of a woman who had four first-trimester miscarriages and a previous child who died at four weeks of age. Ultimately, the diagnosis of NPC was made. In the four patients reported by Daneman, there was a history of perinatal death due to the same disease in a sibling. The diagnosis of LSD was missed at autopsy in each of these siblings, underlining the lack of awareness of LSD as a cause for neonatal ascites.
From the cases reported in the literature it can be concluded that the diagnosis of a high proportion of NIHF, and especially of LSD are missed. As already suggested by Kooper and colleagues, this paper emphasizes the fact that the incidence of LSD may be significantly higher in NIHF than the estimated 1% reported in previous studies. However, the higher incidence could be due to an ascertainment bias, again due to referral to a specialized center for metabolic diseases. But, as also stated by some authors, the given low incidences, in contrast, could be the result of incomplete investigation of NIHF[19, 24].
Transient forms of NIHF and/or ascites in association with LSD as described in this publication in MPS IVA, MPS VII and NPC for the first time must be considered in the differential diagnostic of LSD.
Extensive and thorough investigation for the etiology of NIHF, congenital ascites and transient hydrops as proposed by the diagnostic approach in this publication seems to be obligatory. Enzymatic studies in chorionic villous sample or amniotic cultured cells, once the most common conditions associated with fetal ascitis or hydrops have been ruled out, are important.
A prospective registration and complete examination of all cases of NIHF appears to be mandatory.
Inborn errors of metabolism
Infantile Sialic Acid Storage Disease
Lysosomal storage disease
- ML II:
Mucolipidosis (I-cell disease)
Non-immunological hydrops fetalis
Niemann Pick A disease
Niemann Pick C disease.
- Randenberg AL: Nonimmune hydrops fetalis part I: etiology and pathophysiology. Neonatal Netw. 2010, 29: 281-295. 10.1891/0730-0818.104.22.1681.View ArticlePubMed
- Castillo RA, Devoe LD, Hadi HA, Martin S, Geist D: Nonimmune hydrops fetalis: clinical experience and factors related to a poor outcome. Am J Obstet Gynecol. 1986, 155: 812-816.View ArticlePubMed
- Sohan K, Carroll SG, De La Fuente S, Soothill P, Kyle P: Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment. Acta Obstet Gynecol Scand. 2001, 80: 726-730. 10.1034/j.1600-0412.2001.080008726.x.View ArticlePubMed
- Huang HR, Tsay PK, Chiang MC, Lien R, Chou YH: Prognostic factors and clinical features in liveborn neonates with hydrops fetalis. Am J Perinatol. 2007, 24: 33-38. 10.1055/s-2006-958158.View ArticlePubMed
- Bellini C, Hennekam RC: Non-immune hydrops fetalis: a short review of etiology and pathophysiology. Am J Med Genet A. 2012, 158A: 597-605. 10.1002/ajmg.a.34438.View ArticlePubMed
- Ayida GA, Soothill PW, Rodeck CH: Survival in non-immune hydrops fetalis without malformation or chromosomal abnormalities after invasive treatment. Fetal Diagn Ther. 1995, 10: 101-105. 10.1159/000264214.View ArticlePubMed
- Iskaros J, Jauniaux E, Rodeck C: Outcome of nonimmune hydrops fetalis diagnosed during the first half of pregnancy. Obstet Gynecol. 1997, 90: 321-325. 10.1016/S0029-7844(97)00290-1.View ArticlePubMed
- Swain S, Cameron AD, McNay MB, Howatson AG: Prenatal diagnosis and management of nonimmune hydrops fetalis. Aust N Z J Obstet Gynaecol. 1999, 39: 285-290. 10.1111/j.1479-828X.1999.tb03398.x.View ArticlePubMed
- Kattner E, Schafer A, Harzer K: Hydrops fetalis: manifestation in lysosomal storage diseases including Farber disease. Eur J Pediatr. 1997, 156: 292-295. 10.1007/s004310050603.View ArticlePubMed
- Wraith JE: Lysosomal disorders. Semin Neonatol. 2002, 7: 75-83. 10.1053/siny.2001.0088.View ArticlePubMed
- Burin MG, Scholz AP, Gus R, Sanseverino MT, Fritsh A, Magalhaes JA, Timm F, Barrios P, Chesky M, Coelho JC, Giugliani R: Investigation of lysosomal storage diseases in nonimmune hydrops fetalis. Prenat Diagn. 2004, 24: 653-657. 10.1002/pd.967.View ArticlePubMed
- Staretz-Chacham O, Lang TC, LaMarca ME, Krasnewich D, Sidransky E: Lysosomal storage disorders in the newborn. Pediatrics. 2009, 123: 1191-1207. 10.1542/peds.2008-0635.PubMed CentralView ArticlePubMed
- Hutchison AA, Drew JH, Yu VY, Williams ML, Fortune DW, Beischer NA: Nonimmunologic hydrops fetalis: a review of 61 cases. Obstet Gynecol. 1982, 59: 347-352.PubMed
- Bonduelle M, Lissens W, Goossens A, De Catte L, Foulon W, Denis R, Jauniaux E, Liebaers I: Lysosomal storage diseases presenting as transient or persistent hydrops fetalis. Genet Couns. 1991, 2: 227-232.PubMed
- Denis R, Wayenberg JL, Vermeulen M, Gorus F, Gerlo E, Lissens W, Liebaers I, Jauniaux E, Vamos E: Hyperphosphatasemia in early diagnosed infantile GM1 gangliosidosis presenting as transient hydrops fetalis. Acta Clin Belg. 1996, 51: 320-327.PubMed
- Favre R, Dreux S, Dommergues M, Dumez Y, Luton D, Oury JF, Fiblec BL, Nisand I, Muller F: Nonimmune fetal ascites: a series of 79 cases. Am J Obstet Gynecol. 2004, 190: 407-412. 10.1016/j.ajog.2003.09.016.View ArticlePubMed
- Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E: Etiology of nonimmune hydrops fetalis: a systematic review. Am J Med Genet A. 2009, 149A: 844-851. 10.1002/ajmg.a.32655.View ArticlePubMed
- Bouvier R, Maire I: Diagnosis of lysosomal storage diseases with fetal presentation. Ann Pathol. 1997, 17: 277-280.PubMed
- Gillan JE, Lowden JA, Gaskin K, Cutz E: Congenital ascites as a presenting sign of lysosomal storage disease. J Pediatr. 1984, 104: 225-231. 10.1016/S0022-3476(84)80997-X.View ArticlePubMed
- Machin GA: Hydrops revisited: literature review of 1,414 cases published in the 1980s. Am J Med Genet. 1989, 34: 366-390. 10.1002/ajmg.1320340313.View ArticlePubMed
- Jauniaux E, Van Maldergem L, De Munter C, Moscoso G, Gillerot Y: Nonimmune hydrops fetalis associated with genetic abnormalities. Obstet Gynecol. 1990, 75: 568-572.PubMed
- Groener JE, de Graaf FL, Poorthuis BJ, Kanhai HH: Prenatal diagnosis of lysosomal storage diseases using fetal blood. Prenat Diagn. 1999, 19: 930-933. 10.1002/(SICI)1097-0223(199910)19:10<930::AID-PD664>3.0.CO;2-X.View ArticlePubMed
- Piraud M, Froissart R, Mandon G, Bernard A, Maire I: Amniotic fluid for screening of lysosomal storage diseases presenting in utero (mainly as non-immune hydrops fetalis). Clin Chim Acta. 1996, 248: 143-155. 10.1016/0009-8981(95)06250-5.View ArticlePubMed
- Kooper AJ, Janssens PM, de Groot AN, Liebrand-van Sambeek ML, van den Berg CJ, Tan-Sindhunata GB, van den Berg PP, Bijlsma EK, Smits AP, Wevers RA: Lysosomal storage diseases in non-immune hydrops fetalis pregnancies. Clin Chim Acta. 2006, 371: 176-182. 10.1016/j.cca.2006.03.007.View ArticlePubMed
- Mahony BS, Filly RA, Callen PW, Chinn DH, Golbus MS: Severe nonimmune hydrops fetalis: sonographic evaluation. Radiology. 1984, 151: 757-761.View ArticlePubMed
- Abrams ME, Meredith KS, Kinnard P, Clark RH: Hydrops fetalis: a retrospective review of cases reported to a large national database and identification of risk factors associated with death. Pediatrics. 2007, 120: 84-89. 10.1542/peds.2006-3680.View ArticlePubMed
- McFadden DE, Taylor GP: Cardiac abnormalities and nonimmune hydrops fetalis: a coincidental, not causal, relationship. Pediatr Pathol. 1989, 9: 11-17. 10.3109/15513818909022328.View ArticlePubMed
- Larroche JC, Aubry MC, Narcy F: Intrauterine brain damage in nonimmune hydrops fetalis. Biol Neonate. 1992, 61: 273-280. 10.1159/000243754.View ArticlePubMed
- Stone DL, Sidransky E: Hydrops fetalis: lysosomal storage disorders in extremis. Adv Pediatr. 1999, 46: 409-440.PubMed
- Norton ME: Nonimmune hydrops fetalis. Semin Perinatol. 1994, 18: 321-332.PubMed
- Alegria A, Martins E, Dias M, Cunha A, Cardoso ML, Maire I: Glycogen storage disease type IV presenting as hydrops fetalis. J Inherit Metab Dis. 1999, 22: 330-332. 10.1023/A:1005568507267.View ArticlePubMed
- Rodriguez MM, Bruce JH, Jimenez XF, Romaguera RL, Bancalari E, Garcia OL, Ferrer PL: Nonimmune hydrops fetalis in the liveborn: series of 32 autopsies. Pediatr Dev Pathol. 2005, 8: 369-378. 10.1007/s10024-005-8089-z.View ArticlePubMed
- Applegarth DA, Toone JR, Wilson RD, Yong SL, Baldwin VJ: Morquio disease presenting as hydrops fetalis and enzyme analysis of chorionic villus tissue in a subsequent pregnancy. Pediatr Pathol. 1987, 7: 593-599. 10.3109/15513818709161423.View ArticlePubMed
- Beck M, Braun S, Coerdt W, Merz E, Young E, Sewell AC: Fetal presentation of Morquio disease type A. Prenat Diagn. 1992, 12: 1019-1029. 10.1002/pd.1970121207.View ArticlePubMed
- Cheng Y, Verp MS, Knutel T, Hibbard JU: Mucopolysaccharidosis type VII as a cause of recurrent non-immune hydrops fetalis. J Perinat Med. 2003, 31: 535-537.View ArticlePubMed
- Vervoort R, Islam MR, Sly WS, Zabot MT, Kleijer WJ, Chabas A, Fensom A, Young EP, Liebaers I, Lissens W: Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII. Am J Hum Genet. 1996, 58: 457-471.PubMed CentralPubMed
- Nelson A, Peterson L, Frampton B, Sly WS: Mucopolysaccharidosis VII (beta-glucuronidase deficiency) presenting as nonimmune hydrops fetalis. J Pediatr. 1982, 101: 574-576. 10.1016/S0022-3476(82)80707-5.View ArticlePubMed
- Colmant C, Picone O, Froissart R, Labrune P, Senat MV: Second-trimester diagnosis of mucopolysaccharidosis type IV a presenting as hydrops fetalis. Prenat Diagn. 2006, 26: 750-752. 10.1002/pd.1467.View ArticlePubMed
- Molyneux AJ, Blair E, Coleman N, Daish P: Mucopolysaccharidosis type VII associated with hydrops fetalis: histopathological and ultrastructural features with genetic implications. J Clin Pathol. 1997, 50: 252-254. 10.1136/jcp.50.3.252.PubMed CentralView ArticlePubMed
- Van Dorpe J, Moerman P, Pecceu A, Van den Steen P, Fryns JP: Non-immune hydrops fetalis caused by beta-glucuronidase deficiency (mucopolysaccharidosis VII). Study of a family with 3 affected siblings. Genet Couns. 1996, 7: 105-112.PubMed
- Walter-Nicolet E, Rakza T, Storme L, Vaillant C, Magnenant E, Cremer R, Thumerelle C, Dobbelaere D: A new case of mucopolysaccharidosis VII presenting as non immune hydrops fetalis. Eur J Pediatr. 2003, 162: 520-521. 10.1007/s00431-003-1198-7.View ArticlePubMed
- Leticee N, Bessieres-Grattagliano B, Dupre T, Vuillaumier-Barrot S, de Lonlay P, Razavi F, El Khartoufi N, Ville Y, Vekemans M, Bouvier R, et al: Should PMM2-deficiency (CDG Ia) be searched in every case of unexplained hydrops fetalis?. Mol Genet Metab. 2010, 101: 253-257. 10.1016/j.ymgme.2010.06.009.View ArticlePubMed
- van de Kamp JM, Lefeber DJ, Ruijter GJ, Steggerda SJ, den Hollander NS, Willems SM, Matthijs G, Poorthuis BJ, Wevers RA: Congenital disorder of glycosylation type Ia presenting with hydrops fetalis. J Med Genet. 2007, 44: 277-280. 10.1136/jmg.2006.044735.PubMed CentralView ArticlePubMed
- Dursun A, Gucer S, Ebberink MS, Yigit S, Wanders RJ, Waterham HR: Zellweger syndrome with unusual findings: non-immune hydrops fetalis, dermal erythropoiesis and hypoplastic toe nails. J Inherit Metab Dis. 2009
- Guibaud P, Cottin X, Maire I, Boyer S, Guibaud S, Coicaud C, Bellon-Azzouzi C, Duvernois JP: Fetal ascites as a manifestation of infantile sialidosis. Significance of a study of oligosaccharides in amniotic fluid. J Genet Hum. 1985, 33: 317-324.PubMed
- Godra A, Kim DU, D'Cruz C: Pathologic quiz case: a 5-day-old boy with hydrops fetalis. Mucolipidoses I (Sialidosis III). Arch Pathol Lab Med. 2003, 127: 1051-1052.PubMed
- Beck M, Bender SW, Reiter HL, Otto W, Bassler R, Dancygier H, Gehler J: Neuraminidase deficiency presenting as non-immune hydrops fetalis. Eur J Pediatr. 1984, 143: 135-139. 10.1007/BF00445802.View ArticlePubMed
- Landau D, Meisner I, Zeigler M, Bargal R, Shinwell ES: Hydrops fetalis in four siblings caused by galactosialidosis. Isr J Med Sci. 1995, 31: 321-322.PubMed
- Haverkamp F, Jacobs D, Cantz M, Hansmann M, Fahnenstich H, Zerres K: Nonimmune hydrops fetalis with galactosialidosis: consequences for family planning. Fetal Diagn Ther. 1996, 11: 114-119. 10.1159/000264289.View ArticlePubMed
- Tercanli S, Uyanik G, Hosli I, Cagdas A, Holzgreve W: Increased nuchal translucency in a case of long-chain 3-hydroxyacyl- coenzyme A dehydrogenase deficiency. Fetal Diagn Ther. 2000, 15: 322-325. 10.1159/000021029.View ArticlePubMed
- Tasso MJ, Martinez-Gutierrez A, Carrascosa C, Vazquez S, Tebar R: GM1-gangliosidosis presenting as nonimmune hydrops fetalis: a case report. J Perinat Med. 1996, 24: 445-449. 10.1515/jpme.1922.214.171.1245.View ArticlePubMed
- Steenhout P, Elmer C, Clercx A, Blum D, Gnat D, van Erum S, Vertongen F, Vamos E: Carnitine deficiency with cardiomyopathy presenting as neonatal hydrops: successful response to carnitine therapy. J Inherit Metab Dis. 1990, 13: 69-75. 10.1007/BF01799334.View ArticlePubMed
- Maconochie IK, Chong S, Mieli-Vergani G, Lake BD, Mowat AP: Fetal ascites: an unusual presentation of Niemann-Pick disease type C. Arch Dis Child. 1989, 64: 1391-1393. 10.1136/adc.64.10_Spec_No.1391.PubMed CentralView ArticlePubMed
- Manning DJ, Price WI, Pearse RG: Fetal ascites: an unusual presentation of Niemann-Pick disease type C. Arch Dis Child. 1990, 65: 335-336.PubMed CentralView ArticlePubMed
- Sun CC, Panny S, Combs J, Gutberlett R: Hydrops fetalis associated with Gaucher disease. Pathol Res Pract. 1984, 179: 101-104. 10.1016/S0344-0338(84)80069-2.View ArticlePubMed
- Lake BD, Young EP, Winchester BG: Prenatal diagnosis of lysosomal storage diseases. Brain Pathol. 1998, 8: 133-149.View ArticlePubMed
- Maymon R, Ogle RF, Chitty LS: Smith-Lemli-Opitz syndrome presenting with persisting nuchal oedema and non-immune hydrops. Prenat Diagn. 1999, 19: 105-107. 10.1002/(SICI)1097-0223(199902)19:2<105::AID-PD471>3.0.CO;2-W.View ArticlePubMed
- Meizner I, Levy A, Carmi R, Robinsin C: Niemann-Pick disease associated with nonimmune hydrops fetalis. Am J Obstet Gynecol. 1990, 163: 128-129.View ArticlePubMed
- Trajkovski Z, Vrcakovski M, Saveski J, Gucev ZS: Greenberg dysplasia (hydrops-ectopic calcification-moth-eaten skeletal dysplasia): prenatal ultrasound diagnosis and review of literature. Am J Med Genet. 2002, 111: 415-419. 10.1002/ajmg.10578.View ArticlePubMed
- Schafer A, Harzer K, Kattner E, Schafer HJ, Stoltenburg G, Lietz H: Disseminated lipogranulomatosis (Farber disease) with hydrops fetalis. Pathologe. 1996, 17: 145-149. 10.1007/s002920050148.View ArticlePubMed
- Straub W, Zarabi M, Mazer J: Fetal ascites associated with Conradi's disease (chondrodysplasia punctata): report of a case. J Clin Ultrasound. 1983, 11: 234-236. 10.1002/jcu.1870110414.View ArticlePubMed
- Poulain P, Odent S, Maire I, Milon J, Proudhon JF, Jouan H, Le Marec B: Fetal ascites and oligohydramnios: prenatal diagnosis of a sialic acid storage disease (index case). Prenat Diagn. 1995, 15: 864-867. 10.1002/pd.1970150913.View ArticlePubMed
- Lefebvre G, Wehbe G, Heron D, Vautjoer Brouzes D, Choukroun JB, Darbois Y: Recurrent nonimmune hydrops fetalis: a rare presentation of sialic acid storage disease. Genet Couns. 1999, 10: 277-284.PubMed
- Remes AM, Rantala H, Hiltunen JK, Leisti J, Ruokonen A: Fumarase deficiency: two siblings with enlarged cerebral ventricles and polyhydramnios in utero. Pediatrics. 1992, 89: 730-734.PubMed
- Coughlin EM, Christensen E, Kunz PL, Krishnamoorthy KS, Walker V, Dennis NR, Chalmers RA, Elpeleg ON, Whelan D, Pollitt RJ, et al: Molecular analysis and prenatal diagnosis of human fumarase deficiency. Mol Genet Metab. 1998, 63: 254-262. 10.1006/mgme.1998.2684.View ArticlePubMed
- Ben-Haroush A, Yogev Y, Levit O, Hod M, Kaplan B: Isolated fetal ascites caused by Wolman disease. Ultrasound Obstet Gynecol. 2003, 21: 297-298. 10.1002/uog.73.View ArticlePubMed
- Appelman Z, Blumberg BD, Golabi M, Golbus MS: Nonimmune hydrops fetalis may be associated with an elevated delta OD450 in the amniotic fluid. Obstet Gynecol. 1988, 71: 1005-1008.PubMed
- Valayannopoulos V, Verhoeven NM, Mention K, Salomons GS, Sommelet D, Gonzales M, Touati G, de Lonlay P, Jakobs C, Saudubray JM: Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease. J Pediatr. 2006, 149: 713-717. 10.1016/j.jpeds.2006.08.016.View ArticlePubMed
- Grubbs R, Vugrek O, Deisch J, Wagner C, Stabler S, Allen R, Baric I, Rados M, Mudd SH: S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes. J Inherit Metab Dis. 2010, 33: 705-713. 10.1007/s10545-010-9171-x.View ArticlePubMed
- Pannier E, Viot G, Aubry MC, Grange G, Tantau J, Fallet-Bianco C, Muller F, Cabrol D: Congenital erythropoietic porphyria (Gunther's disease): two cases with very early prenatal manifestation and cystic hygroma. Prenat Diagn. 2003, 23: 25-30. 10.1002/pd.491.View ArticlePubMed
- Reissner K, Tayebi N, Stubblefield BK, Koprivica V, Blitzer M, Holleran W, Cowan T, Almashanu S, Maddalena A, Karson EM, Sidransky E: Type 2 Gaucher disease with hydrops fetalis in an Ashkenazi Jewish family resulting from a novel recombinant allele and a rare splice junction mutation in the glucocerebrosidase locus. Mol Genet Metab. 1998, 63: 281-288. 10.1006/mgme.1998.2675.View ArticlePubMed
- Soma H, Yamada K, Osawa H, Hata T, Oguro T, Kudo M: Identification of Gaucher cells in the chorionic villi associated with recurrent hydrops fetalis. Placenta. 2000, 21: 412-416. 10.1053/plac.1999.0483.View ArticlePubMed
- den Hollander NS, Kleijer WJ, Schoonderwaldt EM, Los FJ, Wladimiroff JW, Niermeijer MF: In-utero diagnosis of mucopolysaccharidosis type VII in a fetus with an enlarged nuchal translucency. Ultrasound Obstet Gynecol. 2000, 16: 87-90. 10.1046/j.1469-0705.2000.00148.x.View ArticlePubMed
- Ramsay SL, Maire I, Bindloss C, Fuller M, Whitfield PD, Piraud M, Hopwood JJ, Meikle PJ: Determination of oligosaccharides and glycolipids in amniotic fluid by electrospray ionisation tandem mass spectrometry: in utero indicators of lysosomal storage diseases. Mol Genet Metab. 2004, 83: 231-238. 10.1016/j.ymgme.2004.07.015.View ArticlePubMed
- Schmidt M, Fahnenstich H, Haverkamp F, Platz H, Hansmann M, Bartmann P: Sialidosis and galactosialidosis as the cause of non-immunologic hydrops fetalis. Z Geburtshilfe Neonatol. 1997, 201: 177-180.PubMed
- Sergi C, Beedgen B, Kopitz J, Zilow E, Zoubaa S, Otto HF, Cantz M, Linderkamp O: Refractory congenital ascites as a manifestation of neonatal sialidosis: clinical, biochemical and morphological studies in a newborn Syrian male infant. Am J Perinatol. 1999, 16: 133-141. 10.1055/s-2007-993847.View ArticlePubMed
- Claeys M, Van der Hoeven M, de Die-Smulders C, Bakker JA, Offermans JP, Forget PP, Groener JE, Spaapen LJ: Early-infantile type of galactosialidosis as a cause of heart failure and neonatal ascites. J Inherit Metab Dis. 1999, 22: 666-667. 10.1023/A:1005546501043.View ArticlePubMed
- Uno Y, Taniguchi A, Tanaka E: Histochemical studies in Wolman's disease–report of an autopsy case accompanied with a large amount of milky ascites. Acta Pathol Jpn. 1973, 23: 779-790.PubMed
- Daneman A, Stringer D, Reilly BJ: Neonatal ascites due to lysosomal storage disease. Radiology. 1983, 149: 463-467.View ArticlePubMed
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