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Table 3 Summary statistics of PD variables

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

PD variables

At baseline

Median (range)

Number of patients

After 6 months of treatment

Median (range)

Number of patients

HbF%

6.3 (0.6 - 30.7)

65

15.7 (3.9 - 41.6)

46

HbF (g/dL)

0.48 (0.04 - 2.7)

63

1.59 (0.34 - 4.04)

46

Hemoglobin (g/dL)

8.8 (6.3 - 11.9)

73

9.6 (6.9 - 14.4)

55

MCV (fL)

90 (68 - 113)

74

111 (81 - 131)

55

MCH (pg)

30 (21 - 36)

73

37 (25 - 44)

55

PMN (109/L)

56 (25 - 80)

71

49 (26 - 86)

53

Platelets (109/L)

428 (122 - 995)

74

316 (109 - 528)

55

Bilirubin (μM)

43 (9 - 96)

75

30 (6 - 113)

53

LDH (UI/L)

355 (155 - 800)

73

317 (168 - 766)

52

Ferritin (μg/L)

346 (16 - 4500)

72

275 (14 - 2940)

52

AST (UI/L)

32 (17 - 79)

75

31 (12 - 81)

53

ALT (UI/L)

22 (7 - 84)

75

21 (7 - 83)

53

Creatinine (μM)

65 (38 - 142)

75

64 (35 - 137)

52

Urea (μM)

2.9 (1.2 - 13.3)

75

3.3 (1.5 - 9)

52