Figure 3

Responsiveness to DGJ and mutant stability. Mutants were divided into four equally populated bins (each including 25% mutations) of increasing predicted stability. For each bin a blue bar shows the percentage of responding mutations, a red bar the percentage of non responding ones. Panel A: bin 1 includes mutations with SDM scores ranging from -11.28 to -2.26; bin 2 from -2.26 to -0.86; bin 3 from -0.73 to 0.25; bin 4 from 0.25 to 3.65. Panel B: bin 1 includes mutations with MUPRO scores ranging from -2.46 to -1.25; bin 2 from -1.25 to -0.95; bin 3 from -0.95 to -0.60; bin 4 from -0.57 to 0.42. Bins with p = 0.01 or p = 0.04 are indicated with ** or * respectively. Box plots for the same data are shown in panel C for SDM and in panel D for MUPRO: the difference between the medians of SDM scores associated with responsive mutations and non responsive mutation is statistically significant (p = 0.03).