From: Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis
Abscess/cellulitis | Positive culture for infectious agent |
---|---|
Bowel (intestinal) bypass syndrome | History of jejunal-ileal bypass surgery for morbid obesity |
Erythema elevatum diutinum | Erythematous asymptomatic plaques often located on the dorsal hands and elbows; younger lesions have microscopic features of leukocytoclastic vasculitis, whereas older lesions have dermal fibrosis and mucin |
Granuloma faciale | Yellow to red to brown indurated asymptomatic facial plaques; there is a grenz zone of normal papillary dermis beneath which there is a dense diffuse inflammatory infiltrate of predominantly neutrophils (with microscopic features of leukocytoclastic vasculitis) and frequently numerous eosinophils |
Halogenoderma | Neutrophilic dermal infiltrate with necrosis and pseudoepitheliomatous hyperplasia with intraepidermal abscesses; history of ingestion of bromides (leg lesions), iodides (facial lesions), or topical fluoride gel to teeth during tumor radiation therapy to face |
Leukemia cutis | Dermal infiltrate consists of immature neutrophils |
Leukocytoclastic vasculitis | Vessel wall destruction – extravasated erythrocytes, fibrinoid necrosis of vessel walls, karyorrhexis, and neutrophils in the vessel wall |
Lobular neutrophilic panniculitides | In addition to subcutaneous Sweet's syndrome, these include alpha 1-antitrypsin deficiency syndrome, factitial panniculitis (secondary to the presence of iatrogenic or self-induced foreign bodies), infectious panniculitis (secondary to either a bacterial, fungal, mycobacterial, or protozoan organism), pancreatic panniculitis, rheumatoid arthritis-associated panniculitis |
Neutrophilic eccrine hidradenitis | Neutrophils around eccrine glands, often in patients with acute myelogenous leukemia receiving induction chemotherapy |
Pyoderma gangrenosum | Painful ulcer with overhanging, undermined violaceous edges |
Rheumatoid neutrophilic dermatitis | History of rheumatoid arthritis, nodules, and plaques |
Sweet's syndrome | Acute onset, fever, neutrophilia, and painful plaques |